Effects of Solvents and Dosing Procedure on Chemical Toxicity in Cell-Based in Vitro Assays

Author:

Tanneberger Katrin1,Rico-Rico Angeles1,Kramer Nynke I.1,Busser Frans J. M.1,Hermens Joop L. M.1,Schirmer Kristin1

Affiliation:

1. Eawag, Swiss Federal Institute of Aquatic Science and Technology, Überlandstrasse 133, 8600 Dübendorf, Switzerland, Institute for Risk Assessment Sciences, University of Utrecht, Yalelaan 2, 3584 CM Utrecht, The Netherlands, and ETH Zürich, Institute of Biogeochemistry and Pollutant Dynamics, Universitätstrasse 16, 8092 Zürich, Switzerland

Publisher

American Chemical Society (ACS)

Subject

Environmental Chemistry,General Chemistry

Reference32 articles.

1. European Commission Regulation (EC) No 1907/2006 of the European Parliament and of the council of 18 December 2006 concerning the Registration, Evaluation, Authorization and Restriction of Chemicals (REACH), establishing a European Chemicals Agency, amending Directive 1999/45/EC and repealing Council Regulation (EEC) No 793/93 and Commission Regulation (EC) No 1488/94 as well as Council Directive 76/769/EEC and Commission Directives 91/155/EEC, 93/67/EEC, 93/105/EC and 2000/21/EC.Off. J. Eur. Union 2006, L396/1, 1−849.

2. Chemical regulators have overreached

3. Non-animal methodologies within biomedical research and toxicity testing

4. Proposal to improve vertebrate cell cultures to establish them as substitutes for the regulatory testing of chemicals and effluents using fish

5. Impact of protein binding on the availability and cytotoxic potency of organochlorine pesticides and chlorophenols in vitro

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