Indolequinone Antitumor Agents: Reductive Activation and Elimination from (5-Methoxy-1-methyl-4,7-dioxoindol-3-yl)methyl Derivatives and Hypoxia-Selective Cytotoxicity in Vitro-Reference-Cited by-同舟云学术

Indolequinone Antitumor Agents: Reductive Activation and Elimination from (5-Methoxy-1-methyl-4,7-dioxoindol-3-yl)methyl Derivatives and Hypoxia-Selective Cytotoxicity in Vitro

Published:1998-06-18 Issue:15 Volume:41 Page:2720-2731
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Naylor Matthew A.¹,Swann Elizabeth¹,Everett Steven A.¹,Jaffar Mohammed¹,Nolan John¹,Robertson Naomi¹,Lockyer Stacey D.¹,Patel Kantilal B.¹,Dennis Madeleine F.¹,Stratford Michael R. L.¹,Wardman Peter¹,Adams Gerald E.¹,Moody Christopher J.¹,Stratford Ian J.¹

Affiliation:

1. Gray Laboratory Cancer Research Trust, P.O. Box 100, Mount Vernon Hospital, Northwood, Middlesex HA6 2JR, United Kingdom, School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Oxford Road, Manchester M13 9PL, United Kingdom, and Department of Chemistry, University of Exeter, Stocker Road, Exeter EX4 4QD, United Kingdom

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm970744w

Reference52 articles.

1. Cyclopropamitosenes, Novel Bioreductive Anticancer Agents. Synthesis, Electrochemistry, and Biological Activity of 7-Substituted Cyclopropamitosenes and Related Indolequinones

2. Cyclopropamitosenes, novel bioreductive anticancer agents. Synthesis of 7-methoxycyclopropamitosene and related indolequinones

3. Reductive activation of potential antitumor mitosene compounds

4. Maliepaard, M. Ph.D. Thesis, Utrecht, 1994.

5. Cyclopropamitosenes

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