De Novo Design of a Picomolar Nonbasic 5-HT1B Receptor Antagonist
Author:
Affiliation:
1. Department of CNS Chemistry
2. Department of Neuroscience Biology
3. Neuroscience Therapeutic Area
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/jm901200t
Reference23 articles.
1. Molecular, pharmacological and functional diversity of 5-HT receptors
2. Alignment of receptor nomenclature with the human genome: classification of 5-HT1B and 5-HT1D receptor subtypes
3. Recent Advances in 5-HT1B / 1D Receptor Antagonists and Agonists and their Potential Therapeutic Applications
4. Helal, C. J.Potent and Selective 5-HT1B/D Antagonists/Inverse Agonists with Reduced hERG Affinity for the Treatment of Depression. Presented at the 235th National Meeting of the American Chemical Society, New Orleans, LA, Apr 6−10, 2008; MEDI-154.
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