MPK-09, a Small Molecule Inspired from Bioactive Styryllactone Restores the Wild-Type Function of Mutant p53-Reference-Cited by-同舟云学术

MPK-09, a Small Molecule Inspired from Bioactive Styryllactone Restores the Wild-Type Function of Mutant p53

Published:2013-04-26 Issue:7 Volume:8 Page:1429-1434
ISSN:1554-8929
Container-title:ACS Chemical Biology
language:en
Short-container-title:ACS Chem. Biol.

Author:

Metri Prashant K.¹,Naz Sarwat¹,Kondaiah Paturu¹,Prasad Kavirayani R.¹

Affiliation:

1. Department of Organic Chemistry and ‡Department of Molecular Reproduction Development and Genetics, Indian Institute of Science, Bangalore 560012, India

Publisher

American Chemical Society (ACS)

Subject

Molecular Medicine,General Medicine,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/cb3005929

Reference26 articles.

1. Awakening guardian angels: drugging the p53 pathway

2. p53—A Natural Cancer Killer: Structural Insights and Therapeutic Concepts

3. Pharmacological reactivation of mutant p53: from protein structure to the cancer patient

4. Hsp90 Is Essential for Restoring Cellular Functions of Temperature-sensitive p53 Mutant Protein but Not for Stabilization and Activation of Wild-type p53

5. The p53 tumor suppressor: A master regulator of diverse cellular processes and therapeutic target in cancer

Cited by 8 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Recent Synthetic Approaches towards Small Molecule Reactivators of p53;Biomolecules;2020-04-20

2. Microsecond molecular dynamics simulations reveal the allosteric regulatory mechanism of p53 R249S mutation in p53-associated liver cancer;Computational Biology and Chemistry;2020-02

3. Unusual Epimerization in Styryllactones: Synthesis of (−)-5-Hydroxygoniothalamin, (−)-5-Acetylgoniothalamin, and O-TBS-Goniopypyrone;ACS Omega;2019-12-17

4. Stereocontrolled Synthesis of Highly Substituted trans α,β-Unsaturated Ketones with Potent Anticancer Properties from Glycals;European Journal of Organic Chemistry;2019-07-17

5. Selective killing of human breast cancer cells by the styryl lactone (R)-goniothalamin is mediated by glutathione conjugation, induction of oxidative stress and marked reactivation of the R175H mutant p53 protein;Carcinogenesis;2018-07-13