A General Approach for the Prediction of the Intestinal Absorption of Drugs: Regression Analysis Using the Physicochemical Properties and Drug–Membrane Electrostatic Interaction

Author:

Sugawara Mitsuru,Takekuma You,HarumiYamada ,MichiyaKobayashi ,Isek Ken,Miyazaki Katsumi

Publisher

American Geophysical Union (AGU)

Subject

Pharmaceutical Science

Reference25 articles.

1. In Vitro Studies of Intestinal Drug Absorption;Alcorn;Determination of Partition and Distribution Coefficients with Brush Border Membrane Vesicles. Biochem. Pharmacol.,1991

2. S.; Conradi, R. A.; Hilgers, A. R. (B) Mechanism of Peptide and Protein Absorption. (2) Transcellular Mechanism of Peptide and Protein Absorption: Passive Aspects. Adv;Burton;Drug Delivery Rev,1991

3. The Influence of Peptide Structure on Transport across Caco-2 Cells;Conradi;Pharm. Res.,1991

4. The Influence of Peptide Structure on Transport across Caco-2 Cells;Conradi;II. Peptide Bond Modification Which Results in Improved Permeability. Pharm. Res.,1992

5. Desolvation Energy: A Major Determinant of Absorption, but Not Clearance, of Peptides in Rats;Karls;Pharm. Res.,1991

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