Reversed Enantioselectivity of Diisopropyl Fluorophosphatase against Organophosphorus Nerve Agents by Rational Design-Reference-Cited by-同舟云学术

Reversed Enantioselectivity of Diisopropyl Fluorophosphatase against Organophosphorus Nerve Agents by Rational Design

Published:2009-11-06 Issue:47 Volume:131 Page:17226-17232
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Melzer Marco¹,Chen Julian C.-H.¹,Heidenreich Anne¹,Gäb Jürgen¹,Koller Marianne¹,Kehe Kai¹,Blum Marc-Michael¹

Affiliation:

1. Blum-Scientific Services, Ledererstrasse 23, 80331 Munich, Germany, Institute of Biophysical Chemistry, Goethe University Frankfurt, Max-von-Laue-Strasse 9, 60438 Frankfurt, Germany, Bundeswehr Institute of Pharmacology and Toxicology, Neuherbergstrasse 11, 80937 Munich, Germany, Institute of Pathology, Johannes Gutenberg University Mainz, 55101 Mainz, Germany, and Institute of Pharmaceutical Chemistry, Philipps University Marburg, 35032 Marburg, Germany

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Link

https://pubs.acs.org/doi/pdf/10.1021/ja905444g

Reference59 articles.

1. Minimalist Active-Site Redesign: Teaching Old Enzymes New Tricks

2. Enzyme Redesign

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4. Crystal structure of diisopropylfluorophosphatase from Loligo vulgaris

5. Binding of a Designed Substrate Analogue to Diisopropyl Fluorophosphatase: Implications for the Phosphotriesterase Mechanism

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