The Complex of a Bivalent Derivative of Galanthamine with Torpedo Acetylcholinesterase Displays Drastic Deformation of the Active-Site Gorge: Implications for Structure-Based Drug Design-Reference-Cited by-同舟云学术

The Complex of a Bivalent Derivative of Galanthamine with Torpedo Acetylcholinesterase Displays Drastic Deformation of the Active-Site Gorge: Implications for Structure-Based Drug Design

Published:2004-11-04 Issue:47 Volume:126 Page:15405-15411
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Greenblatt Harry M.¹,Guillou Catherine¹,Guénard Daniel¹,Argaman Anat¹,Botti Simone¹,Badet Bernard¹,Thal Claude¹,Silman Israel¹,Sussman Joel L.¹

Affiliation:

1. Contribution from the Departments of Structural Biology and Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel, Institut de Chimie des Substances Naturelles, C.N.R.S., Avenue de la Terrasse F-91190 Gif-sur-Yvette CEDEX, France, and BioStrX Ltd., 2a Katzir Street, Ramat Gan, 52656, Israel

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Link

https://pubs.acs.org/doi/pdf/10.1021/ja0466154

Reference62 articles.

1. Bartus, R. T.; Dean, R. L.; Beer, B.; Lippa, A. S.1982,217, 408−414.

2. Alzheimer disease: Lack of effect of lecithin treatment for 3 months

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