Crystal Structures of Highly Constrained Substrate and Hydrolysis Products Bound to HIV-1 Protease. Implications for the Catalytic Mechanism-Reference-Cited by-同舟云学术

Crystal Structures of Highly Constrained Substrate and Hydrolysis Products Bound to HIV-1 Protease. Implications for the Catalytic Mechanism

Published:2008-03-01 Issue:12 Volume:47 Page:3736-3744
ISSN:0006-2960
Container-title:Biochemistry
language:en
Short-container-title:Biochemistry

Author:

Tyndall Joel D. A.¹,Pattenden Leonard K.¹,Reid Robert C.¹,Hu Shu-Hong¹,Alewood Dianne¹,Alewood Paul F.¹,Walsh Terry¹,Fairlie David P.¹,Martin Jennifer L.¹

Affiliation:

1. National School of Pharmacy, University of Otago, P.O. Box 913, Dunedin 9054, New Zealand, Centre for Drug Design and Development, Institute for Molecular Bioscience, University of Queensland, Brisbane QLD 4072, Australia, and Centre for Molecular Biotechnology, Queensland University of Technology, Brisbane QLD 4001, Australia

Publisher

American Chemical Society (ACS)

Subject

Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/bi7023157

Reference50 articles.

1. Protease Inhibitors in the Clinic

2. INHIBITORS OF HIV-1 PROTEASE: A Major Success of Structure-Assisted Drug Design

3. Recent developments in structure-based drug design

4. Darunavir, a conceptually new HIV-1 protease inhibitor for the treatment of drug-resistant HIV

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