Acyl Substitution at the Ortho Position of Anilides Enhances Oral Bioavailability of Thiophene Sulfonamides: TBC3214, an ETA Selective Endothelin Antagonist-Reference-Cited by-同舟云学术

Acyl Substitution at the Ortho Position of Anilides Enhances Oral Bioavailability of Thiophene Sulfonamides: TBC3214, an ETA Selective Endothelin Antagonist

Published:2001-03-13 Issue:8 Volume:44 Page:1211-1216
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Wu Chengde¹,Decker E. Radford¹,Blok Natalie¹,Li Jian¹,Bourgoyne Andree R.¹,Bui Huong¹,Keller Karin M.¹,Knowles Vippra¹,Li Wen¹,Stavros Fiona D.¹,Holland George W.¹,Brock Tommy A.¹,Dixon Richard A. F.¹

Affiliation:

1. Departments of Chemistry, Pharmacology, and Preclinical Toxicology, Texas Biotechnology Corporation, 7000 Fannin, Suite 1920, Houston, Texas 77030

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm000349x

Reference20 articles.

1. Attenuation of pulmonary vascular hypertension and cardiac hypertrophy with sitaxsentan sodium, an orally active ETAreceptor antagonist

2. Acute Endothelin A Receptor Blockade Causes Selective Pulmonary Vasodilation in Patients With Chronic Heart Failure

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