The Discovery of Novel Potenttrans-3,4-Disubstituted Pyrrolidine Inhibitors of the Human Aspartic Protease Renin from in Silico Three-Dimensional (3D) Pharmacophore Searches-Reference-Cited by-同舟云学术

The Discovery of Novel Potenttrans-3,4-Disubstituted Pyrrolidine Inhibitors of the Human Aspartic Protease Renin from in Silico Three-Dimensional (3D) Pharmacophore Searches

Published:2013-03-15 Issue:6 Volume:56 Page:2207-2217
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Lorthiois Edwige¹,Breitenstein Werner¹,Cumin Frederic¹,Ehrhardt Claus¹,Francotte Eric¹,Jacoby Edgar¹,Ostermann Nils¹,Sellner Holger¹,Kosaka Takatoshi²,Webb Randy L.³,Rigel Dean F.³,Hassiepen Ulrich¹,Richert Paul¹,Wagner Trixie¹,Maibaum Jürgen¹

Affiliation:

1. Novartis Pharma AG, Institutes for BioMedical Research, Novartis Campus, CH-4056 Basel, Switzerland

2. Novartis Institutes for BioMedical Research, Ohkubo 8, Tsukuba, Ibaraki 300-2611, Japan

3. Novartis Pharmaceuticals Corp., Institutes for BioMedical Research, East Hanover, New Jersey, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm3017078

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