Asymmetric Synthesis of Optically Active 3-Cyclohexene-1-carboxylic Acid Utilizing Lactic Ester as a Chiral Auxiliary in the Diastereoselective Diels

Asymmetric Synthesis of Optically Active 3-Cyclohexene-1-carboxylic Acid Utilizing Lactic Ester as a Chiral Auxiliary in the Diastereoselective Diels–Alder Reaction

Published:2022-01-28 Issue:3 Volume:26 Page:1002-1009
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Ochiai Hidenori¹^ORCID,Hayashi Wakana¹,Nishiyama Akira¹,Fujita Ryunosuke¹,Kubota Shunichi¹,Sasagawa Miwa¹,Nishi Tatsuya¹

Affiliation:

1. Pharma & Supplemental Nutrition Solutions Vehicle, Pharma Business Division, Kaneka Corporation, 1-8, Miyamae-cho, Takasago-cho, Takasago, Hyogo 676-8688, Japan

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.1c00430

Reference27 articles.

1. Development of an Efficient Manufacturing Process for a Key Intermediate in the Synthesis of Edoxaban

2. Practical, asymmetric synthesis of the cyclohexyl C28-C34 fragment of the immunosuppressant FK-506 via (S)-(−)-3-cyclohexenecarboxylic acid

3. Cheng, P. T. W.; Kaltenbach, R. F., III; Li, J.; Shi, J.; Shi, Y.; Tao, S.; Zhang, H.; Dhanusu, S.; Selvakumar, K.; Reddigunta, R. B.; Walker, S. J.; Kennedy, L. J.; Corte, J. R.; Fang, T.; Jusuf, S. Carbamoyloxymethyl triazole cyclohexyl acid as LPA antagonist. WO 2017223016 A1, 2017.

4. A Short Enantioselective Pathway for the Synthesis of the Anti-Influenza Neuramidase Inhibitor Oseltamivir from 1,3-Butadiene and Acrylic Acid

5. Application of nitrile oxide cycloadditions to a convergent, asymmetric synthesis of (+)-phyllanthocin

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