Practical Synthesis of the Bicyclic Darunavir Side Chain: (3R,3aS,6aR)-Hexahydrofuro[2,3-b]furan-3-ol from Monopotassium Isocitrate-Reference-Cited by-同舟云学术

Practical Synthesis of the Bicyclic Darunavir Side Chain: (3R,3aS,6aR)-Hexahydrofuro[2,3-b]furan-3-ol from Monopotassium Isocitrate

Published:2016-12-22 Issue:1 Volume:21 Page:98-106
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Moore Gary L.¹,Stringham Rodger W.¹,Teager David S.¹,Yue Tai-Yuen¹^ORCID

Affiliation:

1. Clinton Health Access Initiative, 800 North Five Points Road, West Chester, Pennsylvania 19380, United States

Funder

Bill and Melinda Gates Foundation

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

http://pubs.acs.org/doi/pdf/10.1021/acs.oprd.6b00377

Reference19 articles.

1. NIH Guidelines:http://aidsinfo.nih.gov/guidelines(retrieved 22 Sep 2016); WHO Guidelines:http://www.who.int/hiv/pub/arv/arv-2016/en/(published June 2016) .

2. Synthesis and optical resolution of high affinity P2-ligands for HIV-1 protease inhibitors

3. bMartin, M. T.; Roberts, J. C.; Toczko, J. F., US 2006/0148865 A1.

4. Biocatalytic Resolution of Bis-tetrahydrofuran Alcohol

5. Efficient Synthesis of (3R,3aS,6aR)- Hexahydrofuro[2,3-b]furan-3-ol from Glycolaldehyde

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