First-Generation Asymmetric Synthesis of the Selective Estrogen Receptor Degrader GDC-9545 (Giredestrant) Featuring a Highly Efficient Pictet–Spengler Reaction and a C–N Coupling Reaction-Reference-Cited by-同舟云学术

First-Generation Asymmetric Synthesis of the Selective Estrogen Receptor Degrader GDC-9545 (Giredestrant) Featuring a Highly Efficient Pictet–Spengler Reaction and a C–N Coupling Reaction

Published:2021-11-05 Issue: Volume: Page:
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Xu Jie¹^ORCID,Clagg Kyle¹^ORCID,Lim Ngiap-Kie¹^ORCID,Wuitschik Georg²^ORCID,Chung Cheol K.¹^ORCID,Zhang Haiming¹^ORCID,Gosselin Francis¹^ORCID

Affiliation:

1. Department of Small Molecule Process Chemistry, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States

2. Process Chemistry and Catalysis, Small Molecules Technical Development, F. Hoffmann-La Roche Ltd., Grenzacherstrasse, 4070 Basel, Switzerland

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.1c00262

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