Development of a Factory Process for Omecamtiv Mecarbil, a Novel Cardiac Myosin Activator-Reference-Cited by-同舟云学术

Development of a Factory Process for Omecamtiv Mecarbil, a Novel Cardiac Myosin Activator

Published:2019-07-15 Issue:8 Volume:23 Page:1558-1567
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Caille Seb¹^ORCID,Allgeier Alan M.¹,Bernard Charles¹,Correll Tiffany L.²,Cosbie Andrew¹,Crockett Richard D.¹,Cui Sheng³,Faul Margaret M.¹,Hansen Karl B.³,Huggins Seth¹,Langille Neil³,Mennen Steven M.³^ORCID,Morgan Bradley P.⁴,Morrison Henry⁵,Muci Alexander⁴,Nagapudi Karthik⁵,Quasdorf Kyle¹,Ranganathan Krishnakumar¹,Roosen Philipp¹,Shi Xianqing¹,Thiel Oliver R.³,Wang Fang²,Tvetan Justin T.¹,Woo Jacqueline C. S.¹,Wu Steven²,Walker Shawn D.³^ORCID

Affiliation:

1. Drug Substance Technologies, Process Development, Amgen Inc., One Amgen Center Drive, Thousand Oaks, California 91320, United States

2. Attribute Sciences, Amgen, Inc., One Amgen Center Drive, Thousand Oaks, California 91320, United States

3. Drug Substance Technologies, Process Development, Amgen Inc., 360 Binney Street, Cambridge, Massachusetts 02142, United States

4. Research & Nonclinical Development, Cytokinetics, 280 East Grand Avenue, South San Francisco, California 94080, United States

5. Drug Product Technologies, Process Development, Amgen Inc., One Amgen Center Drive, Thousand Oaks, California 91320, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.9b00200

Reference47 articles.

1. Global Public Health Burden of Heart Failure

2. Forecasting the Impact of Heart Failure in the United States

3. Next-generation small molecule therapies for heart failure: 2015 and beyond

4. Cardiac Myosin Activation: A Potential Therapeutic Approach for Systolic Heart Failure

5. Discovery of Omecamtiv Mecarbil the First, Selective, Small Molecule Activator of Cardiac Myosin

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