Synthesis of the Hydrazinyl Pyridine Intermediate: Phase-Appropriate Delivery-Reference-Cited by-同舟云学术

Synthesis of the Hydrazinyl Pyridine Intermediate: Phase-Appropriate Delivery

Published:2017-08-16 Issue:9 Volume:21 Page:1286-1293
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Wilsily Ashraf¹^ORCID,Mennen Steven M.¹,Cosbie Andrew²,Milne Jacqueline E.¹

Affiliation:

1. Process Development, Amgen Inc., 360 Binney Street, Cambridge, Massachusetts 02142, United States

2. Process Development, Amgen Inc., One Amgen Drive, Thousand Oaks, California 91320, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.7b00172

Reference11 articles.

1. Discovery of (R)-6-(1-(8-Fluoro-6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl)ethyl)-3-(2-methoxyethoxy)-1,6-naphthyridin-5(6H)-one (AMG 337), a Potent and Selective Inhibitor of MET with High Unbound Target Coverage and Robust In Vivo Antitumor Activity

2. aICH guidelines limit 1,4-dioxane to 380 ppm due to inherent toxicity, see: ICH Harmonized Tripartite Guideline. Impurities: Guideline for residual solvent.

3. Cyclopentyl Methyl Ether as a New and Alternative Process Solvent

4. Palladium-Catalyzed Suzuki−Miyaura Cross-Coupling Reactions Employing Dialkylbiaryl Phosphine Ligands

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