Exploiting the Physical Properties of Diethanolamine Boronic Esters for Process Improvements in AZD5718-Reference-Cited by-同舟云学术

Exploiting the Physical Properties of Diethanolamine Boronic Esters for Process Improvements in AZD5718

Published:2023-03-09 Issue:3 Volume:27 Page:488-495
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Henry Jean-Marc¹^ORCID,Milne David¹,Perkins Dave¹,Hicks William¹,Hose David R. J.¹^ORCID,Campbell Andrew D.¹,Mullen Alexander K.¹,Inglesby Phillip A.¹^ORCID,Raw Steven A.¹^ORCID,Jones Martin F.¹

Affiliation:

1. Chemical Development, Pharmaceutical Technology & Development, Operations, AstraZeneca, Macclesfield SK10 2NA, U.K.

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.2c00342

Reference31 articles.

1. Initial Clinical Experience with AZD5718, a Novel Once Daily Oral 5-Lipoxygenase Activating Protein Inhibitor

2. Discovery and Early Clinical Development of an Inhibitor of 5-Lipoxygenase Activating Protein (AZD5718) for Treatment of Coronary Artery Disease

3. A Practical Telescoped Three-Step Sequence for the Preparation of (1R,2R)-2-(4-Bromobenzoyl)cyclohexanecarboxylic Acid: A Key Building Block Used in One of Our Drug Development Projects

4. Route Design to Manufacture: Synthesis of the Heterocyclic Fragment of AZD5718 Using a Non-cryogenic Lithiation-Alkoxycarbonylation Reaction

5. A Simple, Modular Method for the Synthesis of 3,4,5-Trisubstituted Pyrazoles

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1. Unsaturated (C(sp2/sp)–B) Boronic Acid Derivatives;Reference Module in Chemistry, Molecular Sciences and Chemical Engineering;2024

2. Isolation of Diethanolamine Boronic Ester Improves Synthesis to AZD5718;Synfacts;2023-05-11