Efficient Multikilogram-Scale Synthesis of PTDSS1 Inhibitor: Development of a Practical and Scalable Optical Resolution Method for Chiral 2,3-Pyrrolidinedione
Author:
Affiliation:
1. Process Technology Research Laboratories (PTRL), Pharmaceutical Technology Division, Technology Supervisory Division, Daiichi Sankyo Co., Ltd., 1-12-1 Shinomiya, Hiratsuka-shi, Kanagawa 254-0014, Japan
Funder
Daiichi-Sankyo
Publisher
American Chemical Society (ACS)
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.4c00056
Reference22 articles.
1. Potent and Selective PTDSS1 Inhibitors Induce Collateral Lethality in Cancers with PTDSS2 Deletion
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3. Blank, J.; Bordas, V.; Cotesta, S.; Guagnano, V.; Rueeger, H.; Vaupel, A. Pyrazolopyrrolidine derivatives and their use in the treatment of disease. US 2014/0349990 A1, November 27, 2014.
4. Pyrrolinone derivatives as a new class of P2X3 receptor antagonists Part 2: Discovery of orally bioavailable compounds
5. Pyrrolinone derivatives as a new class of P2X3 receptor antagonists. Part 3: Structure-activity relationships of pyrropyrazolone derivatives
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