Efficient and Scalable Asymmetric Total Synthesis of (−)-Emetine with Pharmaceutical Grade Quality; First Multigram Scale Synthesis-Reference-Cited by-同舟云学术

Efficient and Scalable Asymmetric Total Synthesis of (−)-Emetine with Pharmaceutical Grade Quality; First Multigram Scale Synthesis

Published:2023-01-24 Issue:2 Volume:27 Page:343-357
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Yamada Masatoshi¹^ORCID,Azuma Kazuki¹,Takizawa Iori¹,Ejima Yuki¹,Yamano Mitsuhisa¹,Satoh Kimio²,Doi Takayuki³^ORCID,Ueda Hirofumi³^ORCID,Tokuyama Hidetoshi³^ORCID

Affiliation:

1. Chemical Research and Development, SPERA PHARMA, Inc., 17-85, Jusohonmachi 2-chome, Yodogawa-ku, Osaka 532-0024, Japan

2. Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, 1-1, Seiryo-machi, Aoba-ku, Sendai 980-0872, Japan

3. Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aza-aoba, Aramaki, Aoba-ku, Sendai 980-8578, Japan

Funder

Ministry of Education, Culture, Sports, Science and Technology

Japan Agency for Medical Research and Development

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.2c00355

Reference21 articles.

1. STRUCTURAL BASIS FOR INHIBITION OF PROTEIN SYNTHESIS BY EMETINE AND CYCLOHEXIMIDE BASED ON AN ANALOGY BETWEEN IPECAC ALKALOIDS AND GLUTARIMIDE ANTIBIOTICS

2. The Emetine Alkaloids

3. Design, Synthesis, and Evaluation of pH-Dependent Hydrolyzable Emetine Analogues as Treatment for Prostate Cancer

4. Emetine suppresses SARS-CoV-2 replication by inhibiting interaction of viral mRNA with eIF4E

5. Different Aspects of Emetine’s Capabilities as a Highly Potent SARS-CoV-2 Inhibitor against COVID-19

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