Systematic Investigation into the Formation of Significant Amounts of Unknown Impurity during Scale-up of NaBH4–I2 Mediated Reduction of Nitro-Amide Intermediate of Mirabegron-Reference-Cited by-同舟云学术

Systematic Investigation into the Formation of Significant Amounts of Unknown Impurity during Scale-up of NaBH4–I2 Mediated Reduction of Nitro-Amide Intermediate of Mirabegron

Published:2020-01-15 Issue:2 Volume:24 Page:286-293
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Deshmukh Dattatray G.¹,Bangal Mukund N.¹,Kalawade Kaustubh A.¹,Mathad Vijayavitthal T.¹^ORCID

Affiliation:

1. Department of Process Research and Development, Megafine Pharma (P) Ltd., 201, Lakhmapur, Dindori, Nashik, Maharashtra 422 202, India

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.9b00365

Reference21 articles.

1. Mirabegron for the treatment of overactive bladder

2. Role of ?-adrenoceptor subtypes in mediating relaxation of the pig bladder trigonal muscle in vitro

3. Maruyama, T.; Suzuki, T.; Onda, K.; Hayakawa, M.; Moritomo, H.; Kimizuka, T.; Matsui, T. Amide derivatives or salt thereof. U.S. Patent 6,346,532, 2002.

4. Kawazoe, S.; Sakamoto, K.; Awamura, Y.; Maruyama, T.; Suzuki, T.; Onda, K.; Takasu, T. α-Form or β-Form Crystals of Acetanilide Derivative. U.S. Patent 7,342,117, 2008.

5. Peddy, V.; Boge, R. Amorphous Mirabegron and Process for Crystal Forms of Mirabegron. Patent WO 2012/156998, 2012.

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