Mapping Polymorphic Behavior of Process Intermediates, an Often-Overlooked Exercise-Reference-Cited by-同舟云学术

Mapping Polymorphic Behavior of Process Intermediates, an Often-Overlooked Exercise

Published:2022-03-01 Issue:4 Volume:26 Page:1258-1267
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Morrison Henry¹^ORCID,Regens Christopher S.¹,Dunetz Joshua R.¹,Lapina Olga¹,Shah Nisha P.¹^ORCID,Burke Brenda J.²,Wenderski Todd¹,Asselin Sylvie M.³,Vieira Tiago⁴^ORCID

Affiliation:

1. Process Chemistry, Gilead Sciences Inc., 333 Lakeside Dr., Foster City, California 94404, United States

2. Process Chemistry, Sanofi, 153 Second Avenue, Waltham, Massachusetts 02451, United States

3. Process Chemistry, Erasca Inc., 10835 Road to the Cure, Suite 140, San Diego, California 92121, United States

4. Process Development, Gilead Alberta ULC, Edmonton, Alberta T6S 1A1, Canada

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.2c00003

Reference11 articles.

1. Development of a Suitable Salt Form for a GPR40 Receptor Agonist

2. Development of a Suitable Physical Form for a Sphingosine-1-phosphate Receptor Agonist

3. Appearance of a New Hydrated Form during Development: A Case Study in Process and Solid-State Optimization

4. Estimation of the transition temperature for an enantiotropic polymorphic system from the transformation kinetics monitored using Raman spectroscopy

5. Selection of a Suitable Physical Form and Development of a Crystallization Process for a PDE10A Inhibitor Exhibiting Enantiotropic Polymorphism

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