1. Department of Technical Analytical Chemistry, Center for Chemistry and Chemical Engineering, Lund University, Box 124, SE-221 00 Lund, Sweden, AstraZeneca R&D Mölndal, SE-431 83 Mölndal, Sweden, and Department of Biochemistry, Center for Chemistry and Chemical Engineering, Lund University, Box 124, SE-221 00 Lund, Sweden