1. Department of Biotechnology, Vanung University, Chungli, Taoyuan, Department of Chemical Engineering, National Tsing Hua University, Hsinchu, Taiwan, ROC, Department of Biological Science and Technology, China Medical University, Taichung, Division of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Zhunan, Miaoli, and Division of Endocrinology and Metabolism, Chung Gung University and Memorial Hospital, Kweishan, Taoyuan, Taiwan, ROC