Multiplexed Single-Molecule Experiments Reveal Nucleosome Invasion Dynamics of the Cas9 Genome Editor-Reference-Cited by-同舟云学术

Multiplexed Single-Molecule Experiments Reveal Nucleosome Invasion Dynamics of the Cas9 Genome Editor

Published:2021-10-01 Issue:40 Volume:143 Page:16313-16319
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Makasheva Kristina¹^ORCID,Bryan Louise C.¹,Anders Carolin²,Panikulam Sherin²,Jinek Martin²,Fierz Beat¹^ORCID

Affiliation:

1. Laboratory of Biophysical Chemistry of Macromolecules, Institute of Chemical Sciences and Engineering (ISIC), École Polytechnique Fédérale de Lausanne (EPFL), Station 6, 1015 Lausanne, Switzerland

2. Department of Biochemistry, University of Zurich, Winterthurerstr. 190, 8057 Zurich, Switzerland

Funder

Howard Hughes Medical Institute

Schweizerischer Nationalfonds zur F??rderung der Wissenschaftlichen Forschung

??cole Polytechnique F??d??rale de Lausanne

Vallee Foundation

H2020 European Research Council

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Link

https://pubs.acs.org/doi/pdf/10.1021/jacs.1c06195

Reference42 articles.

1. Determinants and dynamics of genome accessibility

2. Nucleosomes facilitate their own invasion

3. The Biology of Chromatin Remodeling Complexes

4. Structural transition of the nucleosome during chromatin remodeling and transcription

5. DNA damage detection in nucleosomes involves DNA register shifting

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