Design and Synthesis of Imidazoline Derivatives Active on Glucose Homeostasis in a Rat Model of Type II Diabetes. 2. Syntheses and Biological Activities of 1,4-Dialkyl-, 1,4-Dibenzyl, and 1-Benzyl-4-alkyl-2-(4‘,5‘-dihydro-1‘H- imidazol-2‘-yl)piperazines and Isosteric Analogues of Imidazoline-Reference-Cited by-同舟云学术

Design and Synthesis of Imidazoline Derivatives Active on Glucose Homeostasis in a Rat Model of Type II Diabetes. 2. Syntheses and Biological Activities of 1,4-Dialkyl-, 1,4-Dibenzyl, and 1-Benzyl-4-alkyl-2-(4‘,5‘-dihydro-1‘H- imidazol-2‘-yl)piperazines and Isosteric Analogues of Imidazoline

Published:1999-04-14 Issue:9 Volume:42 Page:1587-1603
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Le Bihan Gaëlle¹,Rondu Frédéric¹,Pelé-Tounian Agnès¹,Wang Xuan¹,Lidy Sandrine¹,Touboul Estéra¹,Lamouri Aazdine¹,Dive Georges¹,Huet Jack¹,Pfeiffer Bruno¹,Renard Pierre¹,Guardiola-Lemaître Béatrice¹,Manéchez Dominique¹,Pénicaud Luc¹,Ktorza Alain¹,Godfroid Jean-Jacques¹

Affiliation:

1. Laboratoire de Pharmacochimie Moléculaire et Systèmes Membranaires, EA 2381, and Laboratoire de Physiopathologie de la Nutrition, CNRS ESA 7059, Université Paris 7-Denis Diderot, 2, place Jussieu, 75251 Paris Cedex 05, France, ADIR, 1, rue Carle Hébert, and IRI Servier, 6, place des Pléiades, 92415 Courbevoie Cedex, France, Centre d'Ingénierie des Protéines, Institut de Chimie, Université de Liège, Belgium, and UPRESA, CNRS 5018/-UPS, Toulouse, France

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm981099b

Reference42 articles.

1. The receptor for antidiabetic sulfonylureas controls the activity of the ATP-modulated K+ channel in insulin-secreting cells.

2. Mechanism of Metformin Action in Non-Insulin-Dependent Diabetes

3. Hermann, L. S.; Melander, A. Biguanides: Basic aspects and clinical uses. InInternational Textbook of Diabetes Mellitus; Alberti, K. G. M. M., De Fronzo, R. A., Keen, H., Zimmet, P., Eds.; John Wiley & Sons Ltd. New York, 1992; pp 773−795.

Cited by 68 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Morpholine, Piperazine, and Piperidine Derivatives as Antidiabetic Agents;Molecules;2024-06-26

2. Green chemistry approach towards Piperazine: anticancer agents;Journal of Molecular Structure;2023-11

3. Metal-free synthesis of imidazoles and 2-aminoimidazoles;Journal of Molecular Structure;2023-01

4. A Highly Efficient and Eco-Friendly Synthesis of Disubstituted Imidazoles in Ionic Liquid from Gem-Dibromo Vinylarenes and Amidines;Polycyclic Aromatic Compounds;2022-04-12

5. A mononuclear PdII complex with Naphcon; crystal structure, experimental and computational studies of the interaction with DNA/BSA and evaluation of anticancer activity;Polyhedron;2021-09