Toward Broad Spectrum Dihydrofolate Reductase Inhibitors Targeting Trimethoprim Resistant Enzymes Identified in Clinical Isolates of Methicillin Resistant Staphylococcus aureus-Reference-Cited by-同舟云学术

Toward Broad Spectrum Dihydrofolate Reductase Inhibitors Targeting Trimethoprim Resistant Enzymes Identified in Clinical Isolates of Methicillin Resistant Staphylococcus aureus

Published:2019-09-30 Issue:11 Volume:5 Page:1896-1906
ISSN:2373-8227
Container-title:ACS Infectious Diseases
language:en
Short-container-title:ACS Infect. Dis.

Author:

Reeve Stephanie M.¹^ORCID,Si Debjani¹,Krucinska Jolanta¹^ORCID,Yan Yongzhao¹,Viswanathan Kishore¹,Wang Siyu²³,Holt Graham T.²³,Frenkel Marcel S.⁴,Ojewole Adegoke A.²³,Estrada Alexavier¹,Agabiti Sherry S.¹,Alverson Jeremy B.⁵,Gibson Nathan D.⁵,Priestley Nigel D.⁵,Wiemer Andrew J.¹^ORCID,Donald Bruce R.²⁴⁶,Wright Dennis L.¹⁷^ORCID

Affiliation:

1. Department of Pharmaceutical Sciences, University of Connecticut, 69 N. Eagleville Road, Storrs, Connecticut 06269, United States

2. Department of Computer Science, Duke University, 308 Research Drive, Durham, North Carolina 27708, United States

3. Program in Computational Biology and Bioinformatics, Duke University, 101 Science Drive, Durham, North Carolina 27708, United States

4. Department of Biochemistry, Duke University Medical Center, 255 Nanaline H. Duke, Durham, North Carolina 27710, United States

5. Department of Chemistry, University of Montana, 32 Campus Drive, Missoula, Montana 59812, United States

6. Department of Chemistry, Duke University, 124 Science Drive, Durham, North Carolina 27708, United States

7. Department of Chemistry, University of Connecticut, 55 N. Eagleville Road, Storrs, Connecticut 06269, United States

Funder

National Institute of Allergy and Infectious Diseases

National Institute of General Medical Sciences

Publisher

American Chemical Society (ACS)

Subject

Infectious Diseases

Link

https://pubs.acs.org/doi/pdf/10.1021/acsinfecdis.9b00222

Reference44 articles.

1. Frieden, T. (2013) Antibiotic resistance threats in the United States, 2013, pp 22–50, Centers for Disease Control, Atlanta, GA.

2. A Pooled Analysis of the Safety and Efficacy of Iclaprim Versus Vancomycin for the Treatment of Acute Bacterial Skin and Skin Structure Infections in Patients With Intravenous Drug Use: Phase 3 REVIVE Studies

3. Characterization of the gene for the chromosomal dihydrofolate reductase (DHFR) of Staphylococcus epidermidis ATCC 14990: the origin of the trimethoprim-resistant S1 DHFR from Staphylococcus aureus?

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