Bcl-2 Antagonist Obatoclax Reactivates Latent HIV-1 via the NF-κB Pathway and Induces Latent Reservoir Cell Apoptosis in Latently Infected Cells

Author:

Zhou Chenliang1,Li Ting2,Xia Muye3,Wu Ziyao1,Zhong Xuelin1,Li Axing1,Rashid Huba Khamis1,Ma Chengnuo1,Zhou Ruijing1,Duan Heng4,Zhang Xuanxuan5,Peng Jie3,Li Lin1

Affiliation:

1. NMPA Key Laboratory for Research and Evaluation of Drug Metabolism, Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, P. R. China

2. Aviation Hygiene Management Division, China Southern Airlines Company Limited, Guangzhou 510406, P. R. China

3. State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou 510515, P. R. China

4. Department of Pharmacy, Stomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou 510280, Guangdong, P. R. China

5. Center for Drug Research and Development, Guangdong Pharmaceutical University, Guangzhou 510006, Guangdong, P. R. China

Funder

Basic and Applied Basic Research Foundation of Guangdong Province

State Administration of Traditional Chinese Medicine of the People's Republic of China

Guangzhou Municipal Science and Technology Project

National Natural Science Foundation of China

Guangdong Medical Research Foundation

Publisher

American Chemical Society (ACS)

Subject

Infectious Diseases

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