Total Synthesis and Structure Assignment of the Relacidine Lipopeptide Antibiotics and Preparation of Analogues with Enhanced Stability

Author:

Al Ayed Karol1,Zamarbide Losada Denise1,Machushynets Nataliia V.2,Terlouw Barbara3,Elsayed Somayah S.2ORCID,Schill Julian4,Trebosc Vincent4,Pieren Michel4,Medema Marnix H.3ORCID,van Wezel Gilles P.2ORCID,Martin Nathaniel I.1ORCID

Affiliation:

1. Biological Chemistry Group, Institute of Biology, Leiden University, Sylviusweg 72, 2333 BE Leiden, Netherlands

2. Molecular Biotechnology Group, Institute of Biology, Leiden University, Sylviusweg 72, 2333 BE Leiden, Netherlands

3. Bioinformatics Group, Wageningen University, Droevendaalsesteeg 1, 6708 PB Wageningen, Netherlands

4. BioVersys AG, c/o Technologiepark, Hochbergerstrasse 60c, CH-4057 Basel, Switzerland

Funder

H2020 European Research Council

Nederlandse Organisatie voor Wetenschappelijk Onderzoek

Publisher

American Chemical Society (ACS)

Subject

Infectious Diseases

Reference19 articles.

1. Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis

2. O’Neill, J. Antimicrobial Resistance: Tackling a Crisis for the Health and Wealth of Nations; Review on Antimicrobial Resistance: London, 2014.

3. O’Neill, J. Tackling Drug-Resistant Infections Globally: Final Report and Recommendations; Review on Antimicrobial Resistance: London, 2016.

4. COVID-19: U.S. Impact on Antimicrobial Resistance, Special Report 2022

5. Federal Funding for the Study of Antimicrobial Resistance in Nosocomial Pathogens: No ESKAPE

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