Dual Action of Eeyarestatin 24 on Sec-Dependent Protein Secretion and Bacterial DNA

Author:

Schäfer Ann-Britt1,Steenhuis Maurice2,Jim Kin Ki34,Neef Jolanda5,O’Keefe Sarah6,Whitehead Roger C.7ORCID,Swanton Eileithyia6,Wang Biwen8,Halbedel Sven910ORCID,High Stephen6,van Dijl Jan Maarten5ORCID,Luirink Joen2,Wenzel Michaela1ORCID

Affiliation:

1. Division of Chemical Biology, Department of Life Sciences, Chalmers University of Technology, 412 96 Gothenburg, Sweden

2. Molecular Microbiology, Amsterdam Institute of Molecular and Life Sciences (AIMMS), Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands

3. Department of Medical Microbiology and Infection Prevention, Amsterdam University Medical Centers - Location Vrije Universiteit Amsterdam, 1081 HZ Amsterdam, The Netherlands

4. Amsterdam Institute for Infection and Immunity, Amsterdam University Medical Centers, 1081 HZ Amsterdam, The Netherlands

5. Department of Medical Microbiology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, PO Box 30001, 9700 RB Groningen, The Netherlands

6. School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9PL, United Kingdom

7. School of Chemistry, Faculty of Science and Engineering, University of Manchester, Manchester M13 9PL, United Kingdom

8. Bacterial Cell Biology and Physiology, Swammerdam Institute for Life Sciences, University of Amsterdam, 1098 XH Amsterdam, The Netherlands

9. FG11 Division of Enteropathogenic Bacteria and Legionella, Robert Koch Institute, 38855 Wernigerode, Germany

10. Institute for Medical Microbiology and Hospital Hygiene, Otto von Guericke University Magdeburg, 39120 Magdeburg, Germany

Funder

Chalmers Tekniska H?gskola

Wellcome Trust

Nederlandse Organisatie voor Wetenschappelijk Onderzoek

Publisher

American Chemical Society (ACS)

Subject

Infectious Diseases

Reference65 articles.

1. Agnew, E.; Dolecek, C.; Hasan, R.; Lahra, M.; Merk, H.; Perovic, O.; Sievert, D.; Smith, R.; Taylor, A.; Turner, P. Global antimicrobial resistance and use surveillance system (GLASS) report; World Health Organization, 2021.

2. Discovery, research, and development of new antibiotics: the WHO priority list of antibiotic-resistant bacteria and tuberculosis

3. Antibiotics in the clinical pipeline at the end of 2015

4. The global preclinical antibacterial pipeline

5. Dissection of the Dislocation Pathway for Type I Membrane Proteins with a New Small Molecule Inhibitor, Eeyarestatin

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