The Tuberculosis Drug Candidate SQ109 and Its Analogs Have Multistage Activity against Plasmodium falciparum

Author:

Watson Savannah J.,van der Watt Mariëtte E.,Theron Anjo1,Reader Janette,Tshabalala Sizwe,Erlank Erica2,Koekemoer Lizette L.2,Naude Mariska,Stampolaki Marianna3,Adewole Feyisola4,Sadowska Katie4,Pérez-Lozano Pilar5ORCID,Turcu Andreea L.6,Vázquez Santiago6ORCID,Ko Jihee7ORCID,Mazurek Ben7ORCID,Singh Davinder7,Malwal Satish R.7ORCID,Njoroge Mathew8,Chibale Kelly89ORCID,Onajole Oluseye K.4,Kolocouris Antonios3ORCID,Oldfield Eric7ORCID,Birkholtz Lyn-MariéORCID

Affiliation:

1. Next Generation Health, Council for Scientific and Industrial Research, Pretoria 0001, South Africa

2. Centre for Emerging Zoonotic and Parasitic Diseases, National Institute for Communicable Diseases of the National Health Laboratory Services, Wits Research Institute for Malaria, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, Johannesburg 2000, South Africa

3. Laboratory of Medicinal Chemistry, Section of Pharmaceutical Chemistry, Department of Pharmacy, National and Kapodistrian University of Athens, Panepistimioupolis-Zografou, 15771 Athens, Greece

4. Department of Biological, Physical and Health Sciences, College of Science, Health & Pharmacy, Roosevelt University, 425 South Wabash Avenue, Chicago, Illinois 60605, United States

5. Department of Pharmacy and Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, Barcelona 08028, Spain

6. Laboratori de Química Farmacèutica (Unitat Associada al CSIC), Departament de Farmacologia, Toxicologia i Química Terapèutica, Facultat de Farmàcia i Ciències de l’Alimentació, and Institute of Biomedicine (IBUB), Universitat de Barcelona, Barcelona E-08028, Spain

7. Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States

8. Drug Discovery and Development Centre (H3D), University of Cape Town, Rondebosch, Capetown 7701, South Africa

9. South African Medical Research Council Drug Discovery and Development Centre, Department of Chemistry and Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Rondebosch, Capetown 7701, South Africa

Funder

Bill and Melinda Gates Foundation

Medicines for Malaria Venture

National Research Foundation

South African Medical Research Council

Publisher

American Chemical Society (ACS)

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