Enhancing the Intrinsic Antiplasmodial Activity and Improving the Stability and Selectivity of a Tunable Peptide Scaffold Derived from Human Platelet Factor 4

Author:

Lawrence Nicole1ORCID,Handley Thomas N. G.23,de Veer Simon J.1ORCID,Harding Maxim D.1,Andraszek Alicja1,Hall Lachlan1ORCID,Raven Karoline D.4ORCID,Duffy Sandra5,Avery Vicky M.5,Craik David J.1ORCID,Malins Lara R.6ORCID,McMorran Brendan J.4

Affiliation:

1. Institute for Molecular Bioscience and Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, The University of Queensland, Brisbane, Queensland 4072, Australia

2. Department of Radiopharmaceutical Sciences, Cancer Imaging, The Peter MacCallum Cancer Centre, Victoria 3000, Australia

3. Sir Peter MacCallum Department of Oncology, The University of Melbourne, Victoria 3010, Australia

4. The John Curtin School of Medical Research, College of Health and Medicine, Australian National University, Canberra, Australian Capital Territory 2601, Australia

5. Discovery Biology, Centre for Cellular Phenomics, School of Environment and Science, Griffith University, Nathan, Queensland 4111, Australia

6. Research School of Chemistry and Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, Australian National University, Canberra, Australian Capital Territory 2601, Australia

Funder

National Health and Medical Research Council

Australian Research Council

Congressionally Directed Medical Research Programs

Griffith University

Publisher

American Chemical Society (ACS)

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