Overcoming an Extremely Drug Resistant (XDR) Pathogen: Avibactam Restores Susceptibility to Ceftazidime for Burkholderia cepacia Complex Isolates from Cystic Fibrosis Patients

Author:

Papp-Wallace Krisztina M.123,Becka Scott A.1,Zeiser Elise T.1,Ohuchi Nozomi4,Mojica Maria F.13,Gatta Julian A.1,Falleni Monica5,Tosi Delfina5,Borghi Elisa5,Winkler Marisa L.16,Wilson Brigid M.1,LiPuma John J.7,Nukaga Michiyoshi4,Bonomo Robert A.12683ORCID

Affiliation:

1. Research Service, Louis Stokes Cleveland Department of Veterans Affairs, 10701 East Boulevard, Cleveland, Ohio 44106, United States

2. Department of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio 44106, United States

3. Department of Biochemistry, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio 44106, United States

4. Department of Pharmaceutical Sciences, Josai International University, 1 Gumyo, Togane City, Chiba, 283-8555 Japan

5. Department of Health Sciences, University of Milan, Via di Rudinì 8, 20142 Milan, Italy

6. Department of Molecular Biology and Microbiology, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio 44106, United States

7. Department of Pediatrics and Communicable Disease, University of Michigan Medical School, 4810 Jackson Road, Ann Arbor, Michigan 48103, United States

8. Department of Pharmacology, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio 44106, United States

Funder

U.S. Department of Veterans Affairs

National Institute of Allergy and Infectious Diseases

Cystic Fibrosis Foundation

Japan Society for the Promotion of Science

Publisher

American Chemical Society (ACS)

Subject

Infectious Diseases

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