The 16,17-Double Bond Is Needed for Irreversible Inhibition of Human Cytochrome P45017α by Abiraterone (17-(3-Pyridyl)androsta-5,16-dien-3β-ol) and Related Steroidal Inhibitors-Reference-Cited by-同舟云学术

The 16,17-Double Bond Is Needed for Irreversible Inhibition of Human Cytochrome P45017α by Abiraterone (17-(3-Pyridyl)androsta-5,16-dien-3β-ol) and Related Steroidal Inhibitors

Published:1998-12-01 Issue:27 Volume:41 Page:5375-5381
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Jarman Michael¹,Barrie S. Elaine¹,Llera Jose M.¹

Affiliation:

1. Cancer Research Campaign Centre for Cancer Therapeutics, Institute of Cancer Research, Cancer Research Campaign Laboratory, 15 Cotswold Road, Sutton, Surrey SM2 5NG, U.K.

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm981017j

Reference23 articles.

1. Novel Steroidal Inhibitors of Human Cytochrome P45017.alpha.-Hydroxylase-C17,20-lyase): Potential Agents for the Treatment of Prostatic Cancer

2. Pharmacology of novel steroidal inhibitors of cytochrome P45017 (17α-hydroxylase/C17–20 lyase)

3. Biochemistry and pharmacokinetics of potent non-steroidal cytochrome P45017α inhibitors

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