Application of Fragment Screening and Fragment Linking to the Discovery of Novel Thrombin Inhibitors-Reference-Cited by-同舟云学术

Application of Fragment Screening and Fragment Linking to the Discovery of Novel Thrombin Inhibitors

Published:2006-01-20 Issue:4 Volume:49 Page:1346-1355
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Howard Nigel¹,Abell Chris¹,Blakemore Wendy¹,Chessari Gianni¹,Congreve Miles¹,Howard Steven¹,Jhoti Harren¹,Murray Christopher W.¹,Seavers Lisa C. A.¹,van Montfort Rob L. M.¹

Affiliation:

1. Astex Therapeutics, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, United Kingdom, and University Chemical Laboratory, Lensfield Road, Cambridge, CB2 1EW, United Kingdom

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm050850v

Reference56 articles.

1. The clot thickens: clues provided by thrombin structure

2. Thrombin inhibitors identified by computer-assisted multiparameter design

3. Progress in the Development of Synthetic Thrombin Inhibitors as New Orally Active Anticoagulants

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