Design and Synthesis of Pyrrolidine-5,5‘-trans-Lactams (5-Oxo-hexahydropyrrolo[3,2-b]pyrroles) as Novel Mechanism-Based Inhibitors of Human Cytomegalovirus Protease. 4. Antiviral Activity and Plasma Stability-Reference-Cited by-同舟云学术

Design and Synthesis of Pyrrolidine-5,5‘-trans-Lactams (5-Oxo-hexahydropyrrolo[3,2-b]pyrroles) as Novel Mechanism-Based Inhibitors of Human Cytomegalovirus Protease. 4. Antiviral Activity and Plasma Stability

Published:2003-09-17 Issue:21 Volume:46 Page:4428-4449
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Borthwick Alan D.¹,Davies Dave E.¹,Ertl Peter F.¹,Exall Anne M.¹,Haley Terry M.¹,Hart Graham J.¹,Jackson Deborah L.¹,Parry Nigel R.¹,Patikis Angela¹,Trivedi Naimisha¹,Weingarten Gordon G.¹,Woolven James M.¹

Affiliation:

1. Department of Medicinal Chemistry CVU UK, Department of Molecular Immunology, Department of Biomolecular Structure, Department of Enzyme Pharmacology, and Department of Virology, GlaxoSmithKline Research and Development, Medicines Research Centre, Gunnels Wood Road, Stevenage, Herts SG1 2NY, United Kingdom

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm030810w

Reference20 articles.

1. Herpesvirus proteases: targets for novel antiviral drugs

2. The Herpesvirus Proteases as Targets for Antiviral Chemotherapy

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