1. The MOE Key Laboratory for Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, 1200 Cai Lun Road, Shanghai 201210, China, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhong Shan Road, Dalian, 116023, China, and Clinical Research Centre, Sarawak General Hospital, Kuching, 93000, Malaysia