Impact of Lipophilic Efficiency on Compound Quality
Author:
Affiliation:
1. Discovery Chemistry, Gedeon Richter plc, 19-21 Gyömrői út, H-1103 Budapest, Hungary
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/jm201388p
Reference36 articles.
1. Lipophilicity in drug discovery
2. Probing the links between in vitro potency, ADMET and physicochemical parameters
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4. Defining optimum lipophilicity and molecular weight ranges for drug candidates—Molecular weight dependent lower logD limits based on permeability
5. Generation of a Set of Simple, Interpretable ADMET Rules of Thumb
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