1. Laboratory of Separation and Reaction Engineering, Departamento de Engenharia Química, Faculdade de Engenharia da Universidade do Porto, and Institute of Molecular Pathology and Immunology of the University of Porto, Rua Dr. Roberto Frias s/n, 4200-465 Porto, Portugal, Medical Faculty of the University of Porto, Alameda Prof. Hernâni Monteiro, 4200-319, Porto, Portugal, and Analiza, Inc. 3615 Superior Avenue, Cleveland, Ohio 44114