Improving RNA Interference in Mammalian Cells by 4‘-Thio-Modified Small Interfering RNA (siRNA): Effect on siRNA Activity and Nuclease Stability When Used in Combination with 2‘-O-Alkyl Modifications-Reference-Cited by-同舟云学术

Improving RNA Interference in Mammalian Cells by 4‘-Thio-Modified Small Interfering RNA (siRNA): Effect on siRNA Activity and Nuclease Stability When Used in Combination with 2‘-O-Alkyl Modifications

Published:2006-02-08 Issue:5 Volume:49 Page:1624-1634
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Dande Prasad¹,Prakash Thazha P.¹,Sioufi Namir¹,Gaus Hans¹,Jarres Russell¹,Berdeja Andreas¹,Swayze Eric E.¹,Griffey Richard H.¹,Bhat Balkrishen¹

Affiliation:

1. Department of Medicinal Chemistry and Antisense Core Research, Isis Pharmaceuticals Inc., Carlsbad, California 92008

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm050822c

Reference66 articles.

1. Double-stranded RNA as a mediator in sequence-specific genetic silencing and co-suppression

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