Spirocyclic Delta Opioid Receptor Agonists for the Treatment of Pain: Discovery of N,N-Diethyl-3-hydroxy-4-(spiro[chromene-2,4′-piperidine]-4-yl) Benzamide (ADL5747)-Reference-Cited by-同舟云学术

Spirocyclic Delta Opioid Receptor Agonists for the Treatment of Pain: Discovery of N,N-Diethyl-3-hydroxy-4-(spiro[chromene-2,4′-piperidine]-4-yl) Benzamide (ADL5747)

Published:2009-08-20 Issue:18 Volume:52 Page:5685-5702
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Le Bourdonnec Bertrand¹²³⁴⁵,Windh Rolf T.¹²³⁴⁵,Leister Lara K.¹²³⁴⁵,Zhou Q. Jean¹²³⁴⁵,Ajello Christopher W.¹²³⁴⁵,Gu Minghua¹²³⁴⁵,Chu Guo-Hua¹²³⁴⁵,Tuthill Paul A.¹²³⁴⁵,Barker William M.¹²³⁴⁵,Koblish Michael¹²³⁴⁵,Wiant Daniel D.¹²³⁴⁵,Graczyk Thomas M.¹²³⁴⁵,Belanger Serge¹²³⁴⁵,Cassel Joel A.¹²³⁴⁵,Feschenko Marina S.¹²³⁴⁵,Brogdon Bernice L.¹²³⁴⁵,Smith Steven A.¹²³⁴⁵,Derelanko Michael J.¹²³⁴⁵,Kutz Steve¹²³⁴⁵,Little Patrick J.¹²³⁴⁵,DeHaven Robert N.¹²³⁴⁵,DeHaven-Hudkins Diane L.¹²³⁴⁵,Dolle Roland E.¹²³⁴⁵

Affiliation:

1. Departments of Chemistry

2. Pharmacology

3. DMPK

4. Preclinical Safety Assessment

5. Adolor Corporation, 700 Pennsylvania Drive, Exton, Pennsylvania 19341

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm900773n