Uncovering the Role of Key Active-Site Side Chains in Catalysis: An Extended Brønsted Relationship for Substrate Deprotonation Catalyzed by Wild-Type and Variants of Triosephosphate Isomerase-Reference-Cited by-同舟云学术

Uncovering the Role of Key Active-Site Side Chains in Catalysis: An Extended Brønsted Relationship for Substrate Deprotonation Catalyzed by Wild-Type and Variants of Triosephosphate Isomerase

Published:2019-09-11 Issue:40 Volume:141 Page:16139-16150
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Kulkarni Yashraj S.¹,Amyes Tina L.²,Richard John P.²^ORCID,Kamerlin Shina C. L.¹^ORCID

Affiliation:

1. Science for Life Laboratory, Department of Chemistry − BMC, Uppsala University, BMC, Box 576, S-751 23 Uppsala, Sweden

2. Department of Chemistry, University at Buffalo, SUNY, Buffalo, New York 14260-3000, United States

Funder

Vetenskapsr?det

Knut och Alice Wallenbergs Stiftelse

Human Frontier Science Program

National Institute of General Medical Sciences

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Link

http://pubs.acs.org/doi/pdf/10.1021/jacs.9b08713

Reference107 articles.

1. Quantum mechanical and molecular mechanical studies on a model for the dihydroxyacetone phosphate-glyceraldehyde phosphate isomerization catalyzed by triose phosphate isomerase (TIM)

2. Simple model for the effect of Glu165 → Asp165 mutation on the rate of catalysis in triose phosphate isomerase

3. Molecular dynamics simulations of “loop closing” in the enzyme triose phosphate isomerase

4. Molecular dynamics simulations of active site mutants of triosephosphate isomerase

5. Anatomy of a Conformational Change: Hinged "Lid" Motion of the Triosephosphate Isomerase Loop

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