False Positives in a Reporter Gene Assay: Identification and Synthesis of Substituted N-Pyridin-2-ylbenzamides as Competitive Inhibitors of Firefly Luciferase-Reference-Cited by-同舟云学术

False Positives in a Reporter Gene Assay: Identification and Synthesis of Substituted N-Pyridin-2-ylbenzamides as Competitive Inhibitors of Firefly Luciferase

Published:2008-07-23 Issue:15 Volume:51 Page:4724-4729
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Heitman Laura H.¹,van Veldhoven Jacobus P. D.¹,Zweemer Annelien M.¹,Ye Kai¹,Brussee Johannes¹,IJzerman Adriaan P.¹

Affiliation:

1. Division of Medicinal Chemistry, Leiden/Amsterdam Center for Drug Research, Leiden University, P.O. Box 9502, 2300 RA Leiden, The Netherlands

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm8004509

Reference27 articles.

1. MECHANISM OF BIOLUMINESCENCE, CHEMI-LUMINESCENCE AND ENZYME FUNCTION IN THE OXIDATION OF FIREFLY LUCIFERIN*,†

2. Cloning of firefly luciferase cDNA and the expression of active luciferase in Escherichia coli.

3. Opiate Analgesics' Dual Role in Firefly Luciferase Activity

4. Reporter gene technology: the future looks bright

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