A Highly Regio- and Stereoselective Carbocupration of Fluoroalkylated Internal Alkynes: A Short Total Synthesis of the Antiestrogenic Drug Panomifene
Author:
Affiliation:
1. Department of Chemistry and Materials Technology, Kyoto Institute of Technology, Matsugasaki, Sakyo-ku, Kyoto 606-8585, Japan
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/ol036440n
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1. Synthesis of the (E) and (Z) isomers of the antiestrogen tamoxifen and its metabolite, hydroxytamoxifen, in tritium-labeled form
2. A nickel-catalyzed carbozincation of aryl-substituted alkynes
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