Diastereospecific Enolate Addition and Atom-Efficient Benzimidazole Synthesis for the Production of L/T Calcium Channel Blocker ACT-280778-Reference-Cited by-同舟云学术

Diastereospecific Enolate Addition and Atom-Efficient Benzimidazole Synthesis for the Production of L/T Calcium Channel Blocker ACT-280778

Author:

Funel Jacques-Alexis¹,Brodbeck Stephan²,Guggisberg Yves³,Litjens Remy⁴,Seidel Thomas³,Struijk Martin⁴,Abele Stefan¹

Affiliation:

1. Process Research Chemistry, Actelion Pharmaceuticals Ltd., Gewerbestrasse 16, CH-4123 Allschwil, Switzerland

2. Technical Operations, Drug Substance, Actelion Pharmaceuticals Ltd., Gewerbestrasse 16, CH−4123 Allschwil, Switzerland

3. Valsynthese SA, Fabrikstrasse 48, CH-3900 Brig, Switzerland

4. CML Europe BV, Vliesvenweg 1, P.O. Box 8, Weert, The Netherlands

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

Reference37 articles.

1. aHilpert, K., Hubler, F., and Renneberg, D.WO/2008/132679A1, 2008.

2. bHubler, F., Hilpert, K., and Renneberg, D.WO/2009/130679A1, 2009.

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