An Assembly Concept for the Consecutive Introduction of Unsymmetrical Disulfide Bonds: Synthesis of a Releasable Multidrug Conjugate of Folic Acid-Reference-Cited by-同舟云学术

An Assembly Concept for the Consecutive Introduction of Unsymmetrical Disulfide Bonds: Synthesis of a Releasable Multidrug Conjugate of Folic Acid

Published:2007-06-29 Issue:16 Volume:72 Page:5968-5972
ISSN:0022-3263
Container-title:The Journal of Organic Chemistry
language:en
Short-container-title:J. Org. Chem.

Author:

Vlahov Iontcho R.¹,Santhapuram Hari Krishna R.¹,Wang Yu¹,Kleindl Paul J.¹,You Fei¹,Howard Stephen J.¹,Westrick Elaine¹,Reddy Joseph A.¹,Leamon Christopher P.¹

Affiliation:

1. Endocyte Inc., 3000 Kent Avenue, Suite A1-100, West Lafayette, Indiana 47906

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/jo070411z

Reference9 articles.

1. Design and regioselective synthesis of a new generation of targeted chemotherapeutics. Part 1: EC145, a folic acid conjugate of desacetylvinblastine monohydrazide

2. Folate-targeted chemotherapy

3. Preclinical Evaluation of EC145, a Folate-VincaAlkaloid Conjugate

4. Derivatives of S-9-fluorenylmethyl-L-cysteine

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