Optimized Protein Kinase Cθ (PKCθ) Inhibitors Reveal Only Modest Anti-inflammatory Efficacy in a Rodent Model of Arthritis-Reference-Cited by-同舟云学术

Optimized Protein Kinase Cθ (PKCθ) Inhibitors Reveal Only Modest Anti-inflammatory Efficacy in a Rodent Model of Arthritis

Published:2014-10-09 Issue:1 Volume:58 Page:333-346
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

George Dawn M.¹,Breinlinger Eric C.¹,Argiriadi Maria A.¹,Zhang Yang²,Wang Jianfei²,Bansal-Pakala Pratima¹,Duignan David B.¹,Honore Prisca³,Lang QingYu⁴,Mittelstadt Scott³,Rundell Lian¹,Schwartz Annette¹,Sun Jiakang²,Edmunds Jeremy J.¹

Affiliation:

1. AbbVie Bioresearch Center, 381 Plantation Street, Worcester, Massachusetts 01605, United States

2. WuXi AppTec (Shanghai) Co., Ltd., 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, P. R. China

3. AbbVie, Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States

4. AbbVie China R&D Center, 5F, North Jin Chuang Building #1, 4560 Jinke Road, Pudong New District, Shanghai 201201, P. R. China

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm5013006

Reference21 articles.

1. Discovery of Selective and Orally Bioavailable Protein Kinase Cθ (PKCθ) Inhibitors from a Fragment Hit

2. George, D. M.; Argiriadi, M. A.; Barth, M.; Bonafoux, D. F.; Breinlinger, E. C.; Dai, L.; Edmunds, J. J.; Friedman, M.; Guillier, F.; Hobson, A. D.; Potin, D.; Thomas, D.; Wang, J.; Wu, W.; Zhang, Y.Triazinone compounds. Patent WO2014089904, 2014.

3. Protein kinase Cθ: a new essential superstar on the T-cell stage

4. Protein Kinase Cθ in T Cell Activation

5. Protein Kinase C (PKC ): A Key Enzyme in T Cell Life and Death

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