1. Division of Pharmacology, Department of Neuroscience, School of Medicine, Federico II University of Naples, Via Sergio Pansini 5, 80131 Naples, Italy, Department of Pharmaceutical and Toxicological Chemistry, Faculty of Pharmacy, Federico II University of Naples, Via Domenico Montesano 49, 80131 Naples, Italy, and Department of Pharmaceutical Science, Faculty of Pharmacy, University of Salerno, Via Ponte don Melillo, 84084 Fisciano (SA), Italy