Design and Pharmacology of N-[(3R)-1,2,3,4-Tetrahydroisoquinolinium- 3-ylcarbonyl]-(1R)-1-(4-chlorobenzyl)- 2-[4-cyclohexyl-4-(1H-1,2,4-triazol- 1-ylmethyl)piperidin-1-yl]-2-oxoethylamine (1), a Potent, Selective, Melanocortin Subtype-4 Receptor Agonist-Reference-Cited by-同舟云学术

Design and Pharmacology of N-[(3R)-1,2,3,4-Tetrahydroisoquinolinium- 3-ylcarbonyl]-(1R)-1-(4-chlorobenzyl)- 2-[4-cyclohexyl-4-(1H-1,2,4-triazol- 1-ylmethyl)piperidin-1-yl]-2-oxoethylamine (1), a Potent, Selective, Melanocortin Subtype-4 Receptor Agonist

Published:2002-09-14 Issue:21 Volume:45 Page:4589-4593
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Sebhat Iyassu K.¹,Martin William J.¹,Ye Zhixiong¹,Barakat Khaled¹,Mosley Ralph T.¹,Johnston David B. R.¹,Bakshi Raman¹,Palucki Brenda¹,Weinberg David H.¹,MacNeil Tanya¹,Kalyani Rubana N.¹,Tang Rui¹,Stearns Ralph A.¹,Miller Randy R.¹,Tamvakopoulos Constantin¹,Strack Alison M.¹,McGowan Erin¹,Cashen Doreen E.¹,Drisko Jennifer E.¹,Hom Gary J.¹,Howard Andrew D.¹,MacIntyre D. Euan¹,van der Ploeg Lex H. T.¹,Patchett Arthur A.¹,Nargund Ravi P.¹

Affiliation:

1. Departments of Chemistry, Pharmacology, Obesity Research, and Drug Metabolism, Merck & Co., Inc., P.O. Box 2000, Rahway, New Jersey 07065-0900

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm025539h

Reference25 articles.

1. Role of melanocortins in the central control of feeding

2. Molecular characterization of the mouse agouti locus

3. Inefficient gene transfer by adenovirus vector to cystic fibrosis airway epithelia of mice and humans

4. Evidence for involvement of the melanocortin MC4 receptor in the effects of leptin on food intake and body weight

Cited by 180 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. α-Melanocyte-stimulating hormone alleviates pathological cardiac remodeling via melanocortin 5 receptor;EMBO Reports;2024-03-07

2. Annotated Bibliography of Dr. Arthur A. Patchett;Journal of Medicinal Chemistry;2023-11-30

3. α-Melanocyte-Stimulating Hormone Regulates Pathological Cardiac Remodeling by Activating Melanocortin 5 Receptor in Cardiomyocytes;2023-04-11

4. Pharmacological Chaperones;Protein Homeostasis in Drug Discovery;2022-11-14

5. Ligands for Melanocortin Receptors: Beyond Melanocyte-Stimulating Hormones and Adrenocorticotropin;Biomolecules;2022-10-01