(S)-N-[1-(3-Morpholin-4-ylphenyl)ethyl]- 3-phenylacrylamide: An Orally Bioavailable KCNQ2 Opener with Significant Activity in a Cortical Spreading Depression Model of Migraine-Reference-Cited by-同舟云学术

(S)-N-[1-(3-Morpholin-4-ylphenyl)ethyl]- 3-phenylacrylamide: An Orally Bioavailable KCNQ2 Opener with Significant Activity in a Cortical Spreading Depression Model of Migraine

Published:2003-06-12 Issue:15 Volume:46 Page:3197-3200
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Wu Yong-Jin¹,Boissard Christopher G.¹,Greco Corinne¹,Gribkoff Valentin K.¹,Harden David G.¹,He Huan¹,L'Heureux Alexandre¹,Kang Shing Hong¹,Kinney Gene G.¹,Knox Ronald J.¹,Natale Joanne¹,Newton Amy E.¹,Lehtinen-Oboma Sanna¹,Sinz Michael W.¹,Sivarao Digavalli V.¹,Starrett, John E.¹,Sun Li-Qiang¹,Tertyshnikova Svetlana¹,Thompson Mark W.¹,Weaver David¹,Wong Henry S.¹,Zhang Lei¹,Dworetzky Steven I.¹

Affiliation:

1. Bristol-Myers Squibb Pharmaceutical Research Institute, 5 Research Parkway, Wallingford, Connecticut 06492, and Department of Medicinal Chemistry, Bristol-Myers Squibb Pharmaceutical Research Institute, 100 de l'Industrie Boulevard, Candiac, Quebec, J5R 1J1, Canada

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm034073f

Reference19 articles.

1. Linkage of ATM to Cell Cycle Regulation by the Chk2 Protein Kinase

2. Inhibition of M-current in cultured rat superior cervical ganglia by linopirdine: Mechanism of action studies

3. Activation of Expressed KCNQ Potassium Currents and Native Neuronal M-Type Potassium Currents by the Anti-Convulsant Drug Retigabine

4. The novel anticonvulsant retigabine activates M-currents in Chinese hamster ovary-cells tranfected with human KCNQ2/3 subunits

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