Efficient Solution-Phase Synthesis of 4,5,7-Trisubstituted Pyrrolo[3,2-d]pyrimidines

Author:

Zhang Weihe1,Liu Jing1,Stashko Michael A.1,Wang Xiaodong1

Affiliation:

1. Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina 27599, United States

Publisher

American Chemical Society (ACS)

Subject

General Chemistry,General Medicine

Reference21 articles.

1. Imamura, S.; Oguro, Y.Preparation of fused heterocyclic derivatives, particularly pyrrolo[3,2-d]pyrimidines and pyrrolo[3,2-b]pyridines, and their use for treating cancer. Int. Patent WO2007004749A1, 2007.

2. N-Phenyl-N′-[4-(5H-pyrrolo[3,2-d]pyrimidin-4-yloxy)phenyl]ureas as novel inhibitors of VEGFR and FGFR kinases

3. Saavedra, O. M.; Claridge, S. W.; Zhan, L.; Raeppel, F.; Vaisburg, A.; Raeppel, S.; Deziel, R.; Mannion, M.; Zhou, N. Z.; Isakovic, L.Thienopyridine and thienopyrimidine derivatives and their preparation, pharmaceutical compositions, and use as inhibitors of VEGF receptor and HGF receptor signaling for treatment of proliferative diseases. Int. Patent WO2007054831A2, 2007.

4. Discovery of pyrrolopyrimidine inhibitors of Akt

5. Bluhm, H.; Hochguertel, M.; Kroth, H.; Essers, M.; Gege, C.; Richter, F.; Taveras, A.Heterobicyclic matrix metalloprotease inhibitors, their preparation, pharmaceutical compositions, and use in therapy. Int. Patent WO2008063669A1, 2008.

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