Formation of Epichlorohydrin, a Known Rodent Carcinogen, Following Oral Administration of 1,3-Dichloro-2-propanol in Rats

Author:

Waidyanatha Suramya1,Gaudette Norman F.2,Hong Yan2,Fennell Timothy R.2

Affiliation:

1. Division of National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, United States

2. RTI International, Research Triangle Park, North Carolina 27709, United States

Funder

National Institute of Environmental Health Sciences

Publisher

American Chemical Society (ACS)

Subject

Toxicology,General Medicine

Reference50 articles.

1. (1992) Toxicological profile for 1,2,3-trichloropropane, pp57–58,Agency for Toxic Substances and Disease Registry, U.S. Public Health Service,Atlanta, GA,http://www.atsdr.cdc.gov/toxprofiles/tp57-c4.pdf.

2. (2005) 1,3-Dichloro-2-propanol [CAS No. 96-23-1]: review of toxicological literature,National Toxicology Program,Research Triangle Park, NC,http://ntp.niehs.nih.gov/ntp/htdocs/Chem_Background/ExSumPdf/dichloropropanol_508.pdf.

3. (2001) Evaluation of certain food additives and food contaminants. WHO technical report series 909,Joint FAO/WHO Expert Committee on Food Additives,Geneva, Switzerland,http://www.who.int/pcs/jecfa/trs909.pdf.

4. (2003) Position paper on chloropropanols, CX/FAC 03/34 35th Session,CCFAC,Arusha, United Republic of Tanzania,ftp://ftp.fao.org/codex/ccfac35/fa03_34e.pdf.

5. Levels of triaryl/alkyl phosphates in human adipose tissue from Eastern Ontario

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